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Laboratory of Chromosomal DNA Replication

Publications (* corresponding author)

Li, N., Gao, Y., Zhang, Y., Yu, D., Lin, W., Feng, J., Li, J., Xu, Z., Zhang, Y., Dang, S., Liu, Y., Zhou, K., Tye, B.*, Li, Q.*, Gao, N.*, Zhai, Y.* (2024) Parental histone transfer caught at the replication fork. Nature 627, 890-897 https://doi.org/10.1038/s41586-024-07152-2

Luo, J., Lam, W.*, Yu, D., Chao, V., Zopfi, M., Khoo, C., Liu, Z., Li, X.D., Zheng, C., Zhai, Y.*, Ti, S.* (2024) Tubulin acetyltransferases access and modify the microtubule luminal K40 residue via anchors in taxine-binding pockets. Nature Structural & Molecular Biology https://doi.org/10.1038/s41594-024-01406-3

Wu, Y., Zhang, Q., Lin, Y., Lam, W., Zhai, Y.* (2024) Replication licensing regulated by a short linear motif within an intrinsically disordered region of origin recognition complex. Nature Communications 15:8039 https://doi.org/10.1038/s41467-024-52408-0

Ding D., Pang, M., Deng, M., Nguyen, T., Sun, X., Xu, Z., Zhang, Y., Zhai, Y., Yan Y., & Ishibashi, T. (2024) Testis-specific H2BFWT disrupts nucleosome integrity through reductions of DNA-histone interactions. Nucleic Acids Research 1-14 https://doi.org/10.1093/nar/gkae825

Zhang, Q., Lam, W., Zhai, Y.* (2024) Assembly and activation of replicative helicases at origin DNA for replication initiation. Current Opinion in Structural Biology 88:102876

https://doi.org/10.1016/j.sbi.2024.102876

Tye, B. & Zhai, Y. (2024) The Origin Recognition Complex: From Origin Selection to Replication Licensing in Yeast and Humans. Biology, 13(1), 13 https://doi.org/10.3390/biology13010013

Xu, Z., Feng, J., Yu, D., Huo, Y., Ma, X., Lam, W., Liu, Z., Li, X., Ishibashi, T., Dang, S.*, & Zhai, Y*. (2023) Synergism between CMG Helicase and Leading Strand DNA Polymerase at Replication Fork. Nature Communications 14:5849 https://doi.org/10.1038/s41467-023-41506-0

Lin, J., Wu, Y., Tian, G., Yu, D., Yang, E., Lam, W., Liu, Z., Jing, Y., Dang, S., Bao, X.*, Wong J.*, Zhai, Y.*, & Li X.*(2023) Menin 'reads' H3K79me2 mark in a nucleosomal context. Science 379, 717-72 https://doi.org/10.1126/science.adc9318

Li, J., Dong, J., Wang, W., Yu, D., Fan, X., Hui, Y., Lee, C., Lam, H., Alary, N., Yang, Y., Zhang, Y., Zhao, Q., Chen, C.*, Tye, B.*, Dang, S.*, & Zhai, Y.* (2023) The Human Pre-replication Complex is an Open Complex. Cell 186, 98-111 https://doi.org/10.1016/j.cell.2022.12.008

Li, N., Gao, N.*, & Zhai, Y.* (2023) DDK promotes DNA replication initiation: mechanistic and structural insights. Current Opinion in Structural Biology 78, 102504

Cheng, J., Li, N., Huo, Y., Dang, S., Tye, B.*, Gao, N.*, and Zhai, Y.* (2022) Structural Insight into the MCM double hexamer activation by Dbf4-Cdc7 kinase. Nature Communications 13:1396

Ding D., Pang, M., Deng, M., Nguyen, T., Sun, X., Xu, Z., Zhang, Y., Zhai, Y., Yan Y., & Ishibashi, T. (2022) Testis-specific H2BFWT disrupts nucleosome integrity through reductions of DNA-histone interactions. bioRxiv https://doi.org/10.1101/2022.07.20.500751

Lee, S., Cheung, M., Li, J., Zhao, Y., Lam, W., Ho, V., Rohs, R., Zhai, Y.*, Leung, D. *, Tye, B.* (2021) Humanizing the Yeast Origin Recognition Complex. Nature Communications12, 33

Deng, L., Chen, C.-L., Zhai, Y., Dong, Y. & Lou, H. (2021) DNA Replication Stress and Cell Fate. Frontiers in Cell and Developmental Biology 9, https://doi.org/10.3389/fcell.2021.778486

Cheng, J., Li, N., Wang, X., Hu, J., Zhai, Y., and Gao, N. (2020) Structural insight into the assembly and conformational activation of autoinhibited human origin recognition complex. Cell Discovery 6, 88

Li, N.*, Lam, W.*, Zhai, Y.*#, Cheng, J.*, Cheng, E., Zhao, Y., Gao, N.# & Tye, B.# (2018) Structure of the origin recognition complex bound to DNA replication origin. Nature 559, 217-222, *Co-first authors # co-corresponding authors https://www.nature.com/articles/s41586-018-0293-x

Zhai, Y.*, Li, N., Jiang, H., Huang, X., Gao, N. *, Tye, B. * (2017) Unique roles played by each of the non-identical MCM subunits in DNA Replication Licensing. Molecular Cell 67, 168-179

Zhai, Y., and Tye, B. (2017) Structure of the MCM2-7 Double Hexamer and Its Implications for the Mechanistic Functions of the Mcm2-7 Complex. in “DNA replication: From Old Principles to New Discovery” Advances in Experimental Medicine and Biology. Springer publisher.

Zhai, Y., Cheng, E., Wu, H., Li, N., Yung, P., Gao, N., and Tye, B. (2017) Open-ringed Structure of the Cdt1-MCM2-7 Complex as a Precursor of the MCM Double Hexamer. Nature Structural & Molecular Biology 24, 300-308

Zhao, T., Wang, Y., Zhai, Y., Qu, X., Ai, F., Du, S., and Loy, M. (2015) A user-friendly two-color super-resolution localization microscope. Optics Express 23, 1879-187

Li, N.*, Zhai, Y.*#, Zhang, Y., Li, W., Yang, M., Lei, J., Tye, B.#, and Gao, N.# (2015) Structure of the Eukaryotic Minichromosome Maintenance Complex at 3.8 Å. Nature 524, 186–191 *Co-first # co-corresponding authors (highlighted in Nature News & Views) https://www.nature.com/articles/nature14685

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